SUTENT 50MG
DESCRIPTION
Sutent 50mg is sold under the brand name Sutent 50mg capsules which is needed to treat a gastrointestinal stromal tumor (GIST) after other medicines (e.g., imatinib) did not work very well. Sutent 50mg belongs Sutent 50mg to the group Sutent 50mg capsules of medicines known as antitumor medication. It prevents the development of cancer cells, which are eventually damaged. Sutent 50mg is a prescriptionSutent 50mg capsules drug which is used under Sutent 50mg the guidance of medical practioners |
sutent 50mg |
INDICATION
Sutent 50mg capsules is prescribed for the therapy of advanced renal cell carcinoma as well as the treatment of gastrointestinal Sutent 50mg capsulesstromal tumor after disease progression on or intolerance to imatinib mesylate.MECHANISM OF ACTION
Sunitinib shows Sutent 50mg capsules antitumor and antiangiogenic properties by prohibiting Sutent 50mg multiple receptor tyrosine kinases, containing platelet-derived growth factors (PDGFRα and PDGFRβ), vascular stent 50mg capsules endothelial Sutent 50mg growth factors (VEGFR1, VEGFR2, and VEGFR3), FMS-like tyrosine kinase-3 (FLT3), colony-stimulating factor type 1 (CSF-1R), and glial Sutent 50mg cell line-derived neurotrophic Sutent 50mg capsules factor receptor (RET).PRODUCT DETAILS:
Brand: SutentIngredients : Sunitinib
Strength : 50mg
Manufactured : Pfizer’s Ltd
Package : 28 capsules in a bottle
ADME
Duration Sutent 50mg of maximum plasma Sutent 50mg capsules concentration of sunitinib Sutent 50mg capsules is between 6 and 12 hours High protein binding was 95 % and 90 % respectively. Mainly metabolized by cytochromeSutent 50mg capsules P450 enzyme, CYP3A4 Elimination of Sutent 50mg capsules mainly via feces 61% and renal excretion is 16% of administrated dose. Sunitinib half-life is 40 – 60 hours Mainly active Sutent 50mg metabolite half-life was 80 – 110 hoursDOSAGE MANAGEMENT
The prescribed Sutent 50mg capsules dose for Gastrointestinal Stromal Tumor is 50 mg PO qDay for 4 weeks, Sutent 50mg capsules continued by 2 weeks drug-free, repeat cycle. The prescribed dose for Renal Cell Carcinoma is 50 mg Sutent 50mg capsules PO qDay for 4 weeks, followed by 2 weeks drug-free, repeat cycle. Adjuvant treatment of RCC
• Sutent 50mg capsules Prescribed for the adjuvant therapy of adult patients at maximum risk of relapsed RCC following nephrectomy
• The Prescribed dose is Sutent 50mg capsules 50 mg PO qDay for 4 weeks, continued by 2 weeks drug-free, repeat cycle for a maximum of nine 6-week cycles totally Pancreatic Neuroendocrine Tumor NecessarySutent 50mg capsules for progress, well-differentiated pancreatic neuroendocrine tumor (pNET) in patients with unresectable locally advanced or metastatic disease The prescribed dose for Pancreatic Neuroendocrine Tumor is 37.5 mg PO qDay continuously without a scheduled off-treatment period
PRECAUTIONS
• While using of Sutent 50mg, Hypothyroidism occurred; check the baseline thyroid function in patients with hypothyroidism or hyperthyroidism and treat per standard medical practice before to initiating treatment
• While using of Sutent 50mg capsules will have Impaired wound healing resulted; temporary interfere with treatment recommended if go through major surgical procedures
• When treatment Sutent 50mg will causes severe hepatotoxicity involving liver failure; check liver function tests before starting treatment.
• When treatment Sutent 50mg capsules Haemorrhagic events involving tumor-related haemorrhage resulted; test the serial complete blood counts and physical examinations
• When Sutent 50mg treatment Sutent 50mg, Adrenal haemorrhage occurred in animal studies; check the adrenal function in case of stress such as surgery, trauma or severe infection
• While on treatment with Sutent 50mg, regulate urine protein; prohibit treatment for 24-hr urine protein ≥3 g; discontinue for repeat episodes of protein ≥3 g despite dose reductions or nephrotic syndrome
SIDE EFFECTS:
Common side effects :
Sutent 50mg capsules Hives, Breathing difficulty, Sore throat, Skin pain, Red or PurpleSutent 50mg capsules skin rash Upper stomach pain, Itching, Sutent 50mg capsules Tried feeling, Decreased appetite, Dark urine, Jaundice.Serious side effects :
Tiredness,Sutent 50mg capsules decreased urination, Slow heart rate. Thyroid problem Swelling in ankles or feet, Shortness of breath, Sutent 50mg Unusual bruising, Muscle cramps, Fast heart beats, Sudden dizziness.EMAIL :millionhealthpharmaceuticals@gmail.com
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