OLAPARIB 50MG(BREAST CANCER)
DESCRIPTION
Olaparib 50mg capsules is a generic form of brand name Lynparza. Which is required for some types of ovarian cancer that have come back after treatment. It is for people whohave a alter in a gene called BRCA Olaparib 50mg and have had a variety of chemotherapy called Olaparib 50mg platinum Lynparza which used asprescription drug which used under the supervision of medical practioners |
| olaparib 50mg capsules |
INDICATION
Lynparza is an Olaparib 50mg capsules antitumor medication which isIndicated for the treatment in patients with advanced ovarian cancer
Indicated for the treatment in Olaparib 50mg patients with HER2 – negative metastatic breast cancer.
MECHANISM OF ACTION
Olaparib belongs to poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, containing PARP1, PARP2, and PARP3. PARP enzymes are Olaparib 50mg capsules included in DNA transcription, cell cycle Olaparib 50mg managing, and DNA repair.Olaparib consist of anefficient oral PARP inhibitor thatactivates synthetic lethality in BRCA1/2 deficient cancer cells via the formation Olaparib 50mg capsules of double-stranded DNA breaks that cannot be exactly repaired, which causesinterruption of cellular homeostasis and cell death
PRODUCT DETAILS
Ingredients : Olaparib
Strength : 50mg
Package : 112 capsules
price :olaparib 50mg capsules
ADME
High plasma concentration 1 to 3 hours
ADME
plasma protein binding is 82%Volume of distribution 167 +/-196 L
Primarily metabolised by CYP3A4
Excreted via urine 44% and 42% through the feces.
Lynparza Half – life is 11.9 hours
DOSAGE MANAGEMENT
Ovarian cancer :
Maintenance treatment of relapsed Olaparib 50mg capsules ovarian cancerThe tablet prescribed dose is 300mg (two 150mg – mg tablets) PO BID
Follow treatment until disease progression or unacceptable toxicity
Single treatment for Olaparib 50mg advanced BRCA – mutated ovarian cancer
The tablet prescribed dose is 300mg (two 150mg – mg tablets) PO BID
The capsules recommended dose is 400mg (eight 50mg- mg capsules) PO BID
Follow treatment until disease progression or unacceptable toxicity.
Support treatment Olaparib 50mg for advanced BRCA-mutated Olaparib 50mg capsules ovarian cancer
The tablet prescribed dose is 300mg administer two 150mg – mg tablets PO BID
Continue the therapy until disease progression, undesirable toxicity or completion of 2 years of treatment
Finishing of 2 years of treatment :
• Full response of drug to patients (no radiologic evidence): discontinue treatment
• Patients with symptoms of disease and may asset from continuous treatment treat beyond 2 years.
PRECAUTIONS
While on therapy with drug will causeHaematological toxicity in patientsincluding diagnoses or findings of commonly mild or Olaparib 50mg capsules moderate anaemia, neutropenia, thrombocytopenia Olaparib 50mg and lymphopenia.Monotherapy administration of Lynparza to patient the incidence of myelodysplastic syndrome will occur.
On basis of mechanism of action (PARP inhibition), Lynparza Olaparib 50mg capsules could cause fetal harm when administered to a pregnant woman.
Lynparza concomitant use with strong or moderate CYP3A inhibitors is not recommended.
SIDE EFFECTS
Common side effects for patients taking Olaparib :• Musculoskeletal pain
• Diarrhea
• Decreased platelet count
• Decreased Haemoglobin
• Nausea
• Decreased white blood cell count
• Abdominal pain
• Vomiting
• Upper respiratory tract infection
• Anemia
• Decreased neutrophils
• Fatigue (including weakness)
• Increased serum creatinine
Less common side effects of patients administrating Olaparib :
• Vertigo
• Constipation
• Urinary tract infection
• Heartburn
• Decreased appetite
• Shortness of breath
• Myalgia
• Headache
• Skin rash
• Back pain
• Taste changes
• Cough
• Swelling
FOR MORE INFORMATION
EMAIL ID : millionhealthpharmaceuticals@gmail.com
PHONE NO : +91-9940472902
WEBSITE :https://millionpharma.com/olaparib-50mg.php
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