Votrient 400mg - Anticancer drugs | view uses, side effects and price | MHP

                              PAZOPANIB 400MG

DESCRIPTION

                              pazopanib 400mg (pazopanib) is a type of protein kinase inhibitors. It is also indicated for the treatment of advanced kidney cancer and soft tissue sarcoma

  pazopanib 400mg tablet is an antineoplastics medications which interfere with the development and spreadness of cancer cells in the body.

    pazopanib 400mg 

                                   USAGE

  pazopanib 400mg tablet is an effective inhibitor of protein kinase and selective multiple receptor tyrosine kinases (RTKs) that are described in beginning of signal transduction pathways that ready for reproduction of tumor cells and affect processes critical to cell survival and tumor progression. RTKs comes in the blockage and involves the receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor.

                          MECHANISM OF ACTION

  pazopanib 400mg tablet is an effective inhibitor of protein kinase and selective multiple receptor tyrosine kinases (RTKs) that are described in beginning of signal transduction pathways that ready for reproduction of tumor cells and affect processes critical to cell survival and tumor progression. RTKs comes in the blockage and involves the receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor

                           PHARMACOKINETIC

ABSORPTION

                           Fast GI absorption with food and Bioavailability is 14-39%. Time of high plasma concentration: 2-4 hr.

DISTRIBUTION

                        bounding of human protein of pazopanib 400 mg is >99%.

METABOLISM

                       Mainly in the liver pazopanib 400 mg metabolized by CYP3A4 enzyme and to a lesser extent by CYP1A2 and CYP2C8 enzymes.

ELIMINATION

                       pazopanib primarily excreted through faces approx 82%, 67% as unchanged drug and urine (<4%)with renal elimination. Terminal Elimination half-life: Approx 31 hr.

PRODUCT DETAILS

Brand : Votrient
Ingredients : Pazopanib
Strength : 400mg
Manufactured : GlaxoSmithKline Pharmaceuticals
Package : 30 Tablets

DOSAGE & ADMINISTARTION

                 pazopanib 400mg tablet dosage for renal cell carcinoma and soft tissue sarcoma (cancer in joints, muscle) will be initially 800mg , the dose adjustment in 400 mg increments or decrements dose based on tolerance but max dose in adult is 800mg/day. Moderate total bilirubin >1.5 to 3 times, Votrient dose of 400 mg once daily.   pazopanib 400mg should be taken on a empty stomach (1hr before or 2hr after meals. Swallow the medicine whole don’t chew/crush. Food interaction :Avoid grapefruit juice or grapefruit juice.

OVERDOSAGE

                         overdose of the drug can be upto 2000mg can be administrated and It is evaluated in clinical trials and treatment of overdose with votrient should consist of supportive measures and there is no specific antidote.

DOSAGE & ADMINISTARTION

                         pazopanib 400mg  dosage for renal cell carcinoma and soft tissue sarcoma (cancer in joints, muscle) will be initially 800mg , the dose adjustment in 400 mg increments or decrements dose based on tolerance but max dose in adult is 800mg/day. Moderate total bilirubin >1.5 to 3 times, Votrient dose of 400 mg once daily. The   pazopanib 400mg tablet should be taken on a empty stomach (1hr before or 2hr after meals. Swallow the medicine whole don’t chew/crush. Food interaction :Avoid grapefruit juice or grapefruit juice.

OVERDOSAGE

                      overdose of the drug can be upto 2000mg can be administrated and It is evaluated in clinical trials and treatment of overdose with votrient should consist of supportive measures and there is no specific antidote.

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